Endocrine Abstracts

Introduction: Prader-Willi syndrome (PWS) is a neurobehavioral imprinting disorder, which arises due to an absence of paternally expressed genes within the 15q11.2-q13 region. It is the most common syndromic form of obesity, with an estimated prevalence of about 1 in 25,000 individuals.Case report: we report the case of two monozygotic twins, 20-year-old, naturally conceived, both affected by PWS. They were born by eutocic delivery at 34 weeks of gestati...

Introduction: Amiodarone is a widely used antiarrhythmic drug for refractory atrial or ventricular tachyarrhythmias. Amiodarone-induced thyrotoxicosis (AIT) occurs in up to 6% of patients taking this medication in iodine-sufficient areas of the world and in up to 10% in iodine deficient areas. AIT can be divided into two types: type 1 is a form of iodine-induced hyperthyroidism whereas type 2 is a drug-induced destructive thyroiditis. Type 1 AIT tends to occur in patients with...

Introduction: Insulinoma is a rare pancreatic endocrine tumor derived from ß cells that secret insulin, which results in hypoglycemia. Most are benign and solitary. The median age at diagnosis is about 47 years. The age range for peak incidence is between 30 and 60 years and it is more prevalent in women. Diagnosis relies on clinical features along with laboratory tests and imaging. However, the nonspecific symptoms and small size of these tumors can lead to difficulties ...

Introduction: Hyperparathyroidism is a disease characterized by excessive secretion of parathyroid hormone (PTH). There are three main etiologies: primary (PHPT), secondary (SHPT) and tertiary hyperparathyroidism (THPT). PHPT is characterized by abnormal regulation of PTH secretion by calcium, resulting in hypersecretion of PTH relative to the serum calcium concentration. SHPT is the overproduction of PTH in context of hypocalcemia, most frequently because of vitamin D deficie...

Introduction: Autosomal dominant hypocalcemia (ADH) is a rare condition, caused by activating mutations in the calcium-sensing receptor (CASR) gene. Affected individuals have hypocalcemia with inappropriately low parathyroid hormone (PTH) levels.Case report: A 50-year-old woman, asymptomatic, was referred to our Endocrinology department for investigation of hypocalcemia detected in routine blood analysis (serum corrected calcium was 7.4 mg/dl &#...

Abstract: We report the case of a 65-year-old man who presented with erectile dysfunction to an appointment in our Endocrinology department. He referred fatigue, weight gain and constipation as secondary complaints that had been steadily evolving throughout the past 4 years. He denied other symptoms such as visual impairment or headaches as well as the consumption of any medications or drugs. His past medical history was unremarkable. On examination, BMI was 25.8 kg/m2</s...

Introduction: Positive radiotracer uptake by the thyroid gland can occur in PET-CT. It’s meaning has led to conflicting results mainly resulting from small studies.Objective: We aim to present a large single institution consecutive case series.Material and methods: Observational, descriptive and retrospective study of the PET-CT scans performed between the years 2000–2017. We searched the word thyroid in the computer imag...

: We report the case of a 57-year-old female diagnosed with Grave’s disease fifteen years before (TSH <0.001 U/ml; FT4 2.3 ng/dl; FT3 7.2 ng/dl, TSAbs 17 U/l). Persistency of hyperthyroidism despite antithyroid therapy led to total thyroidectomy three years after the diagnosis. Thereafter, thyroid function remained normal under hormonal replacement with levothyroxine. The patient had also been diagnosed with Pernicious Anemia at 47 years of age after investigation for...

We report the case of a Caucasian woman presenting with a challenging differential diagnosis of ophtalmopathy. The patient was diagnosed with Graves’ disease during postpartum at the age of 28 (TSH<0.001 U/ml; FT3 6.7 ng/dl; FT4 2.2 ng/dl; TSAb 15 U/l). Besides 16 pack-year smoking history, no other previous disease was known. At examination, exophthalmos grade I/III with bilateral lid retraction was evident. Persistency of the disease despite optimal use of medical a...

Objective: The aim of this study was to evaluate the treatment outcomes in patients with autonomous toxic nodule (ATN) that received a radioiodine treatment (RAIT) and to determine the influence of age, gender, nodule size and iodine activity.Methods: We performed a retrospective study of all RAIT done for hyperthyroidism (n=149) in our hospital during 2014 and 2015. Patients with ATN submitted to RAIT were selected to analysis. We studied 58 pa...